|
KMID : 0363320070280020377
|
|
Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 2 p.377 ~ p.384
|
|
|
Effects of Acanthopanax sessiliflorus on Immune Cells such as Thymocytes, Splenocytes and Macrophages in Mice
|
|
Kim Hyung-Woo
Kim Gye-Yeop
Jeon Byung-Gwan
Choi Jeong-Sik
Jeong Hyun-Woo
Cho Su-In
|
|
|
Abstract
|
|
|
Objective : Immune potentiation including activation of T cells, B cells, macrophages, and dendritic cells is known to play a key role in prevention and treatment of patients with cancer. In this study, we investigated the effects of Acanthopanax sessiliflorus (AR) on the immune system, especially on thymocytes, splenocytes, and macrophages.
Methods : We investigated the effects of AR on proliferation of splenocytes in normal mice, and the effects on proliferation of splenocytes and thymocytes in tumor-bearing mice. In addition, the effect of AR on NO production using macrophages was investigated.
Results : Treatment with AR accelerated proliferation of splenocytes in vitro. AR also accelerated thymocyte proliferation, but did not affect splenocytes proliferation in normal mice. In contrast, AR accelerated proliferation of splenocytes and thymocytes significantly in tumor bearing mice. In addition, NO production level from macrophages was elevated by treatment with AR.
Conclusion : These results demonstrate that AR has anti-cancer activities and related mechanisms are involved in immune potentiation such as acceleration of immune cell proliferation and elevation of NO production level in macrophages. In addition, we also demonstrate the possibilities of AR as complementary and alternative medicine to standard anti-cancer drugs.
|
|
|
KEYWORD
|
|
|
Acanthopanax sessiliflorus (五加皮), Herbal medicine, Immune-potentiation, Anti-cancer
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|